Trigocherrierin A, a Potent Inhibitor of ChikungunyaVirus Replication

Molecules

Mélanie Bourjot¹  Vincent Dumontet²  Marc Litaudon²  Pieter Leyssen³  Johan Neyts³ 

[1] EA4267 Epithelial Functions and Dysfunctions, UFR of Medical and Pharmaceutical Sciences,19 rue Ambroise Paré, 25030 Besançon, France;Gif Research Center, Institute of Chemistry of Natural Substances (ICSN), CNRS, Labex CEBA, 1, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France;Rega Institute for Medical Research (KU Leuven), Minderbroedersstraat 10, B3000, Leuven, Belgium;

关键词: Trigonostemon cherrieri;    Euphorbiaceae;    chikungunya virus (CHIKV);    daphnane diterpenoid orthoester (DDO);   

DOI  :  10.3390/molecules19033617

来源: DOAJ

【 摘 要 】

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity(EC50 = 0.6 ± 0.1 µM, SI = 71.7).

【 授权许可】

Unknown