Vector Competence of Mediterranean Mosquitoes for Rift Valley Fever Virus: A Meta-Analysis

Pathogens

Thomas Balenghien¹  Véronique Chevalier¹  Benoit Durand²  Alex Drouin² 

[1] ASTRE, University of Montpellier, CIRAD, INRAE, 34398 Montpellier, France;Epidemiology Unit, Laboratory for Animal Health, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), University Paris-Est, 94701 Maisons-Alfort, France;

关键词: Rift Valley fever virus;    mosquito;    competence;    meta-analysis;    Mediterranean Basin;   

DOI  :  10.3390/pathogens11050503

来源: DOAJ

【 摘 要 】

Rift Valley fever (RVF) is a zoonotic disease caused by a virus mainly transmitted by Aedes and Culex mosquitoes. Infection leads to high abortion rates and considerable mortality in domestic livestock. The combination of viral circulation in Egypt and Libya and the existence of unregulated live animal trade routes through endemic areas raise concerns that the virus may spread to other Mediterranean countries, where there are mosquitoes potentially competent for RVF virus (RVFV) transmission. The competence of vectors for a given pathogen can be assessed through laboratory experiments, but results may vary greatly with the study design. This research aims to quantify the competence of five major potential RVFV vectors in the Mediterranean Basin, namely Aedes detritus, Ae. caspius, Ae. vexans, Culex pipiens and Cx. theileri, through a systematic literature review and meta-analysis. We first computed the infection rate, the dissemination rate among infected mosquitoes, the overall dissemination rate, the transmission rate among mosquitoes with a disseminated infection and the overall transmission rate for these five mosquito species. We next assessed the influence of laboratory study designs on the variability of these five parameters. According to experimental results and our analysis, Aedes caspius may be the most competent vector among the five species considered.

【 授权许可】

Unknown