MCM-41 mesoporous silica: a highly efficient and recoverable catalyst for rapid synthesis of α-aminonitriles and imines

Green Chemistry Letters and Reviews

Mohammad G. Dekamin¹  Mohammad Eslami¹  Ali Maleki¹  Leila Motlagh¹ 

[1] Pharmaceutical and Biologically-Active Compounds Research Laboratory, Iran University of Science and Technology;

关键词: MCM-41 mesoporous silica;    α-aminonitriles;    multicomponent reactions (MCRs);    heterogeneous catalysis;    green chemistry;   

DOI  :  10.1080/17518253.2017.1421269

来源: DOAJ

【 摘 要 】

In this work, pure MCM-41 mesoporous silica with active mesoporous sites has been successfully applied, as a highly efficient and recoverable catalyst, for the rapid and convenient synthesis of α-aminonitriles and imines. Various imines, as the intermediate of the Strecker reaction, were simply prepared from condensation of a wide range of aldehydes and amines in the presence of low loading of MCM-41 mesoporous silica under solvent-free conditions at room temperature in high to quantitative yields. Furthermore, the corresponding α-aminonitrile derivatives were prepared through the three-component Strecker reaction using trimethylsilylcyanide catalyzed by MCM-41 as a bifunctional heterogeneous mesoporous solid catalyst.

【 授权许可】

Unknown