Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA

Frontiers in Plant Science

关键词: SUMOylation;    SUMO E3 ligases;    abiotic stress;    structure-function analysis;    DNA-binding proteins;   

DOI  :  10.3389/fpls.2021.652170

来源: DOAJ

【 摘 要 】

Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses. Mechanistically, SUMOylation is a sequential multi-enzymatic process where SUMO E3 ligases accelerate SUMO conjugation while also influencing target identity and interactions. This review explores the biological functions of plant SUMO E3 ligases [SAP AND MIZ1 DOMAIN-CONTAINING LIGASE (SIZs), METHYL METHANESULFONATE-SENSITIVITY PROTEIN 21 (MMS21s), and PROTEIN INHIBITOR OF ACTIVATED STAT-LIKE (PIALs)] in relation to their molecular activities and domains. We also explore the sub-cellular localization of SUMO E3 ligases and review evidence suggesting a connection between certain SUMO E3 ligases and DNA that contributes to gene expression regulation.

【 授权许可】

Unknown