Stem-cell treatment in disc degeneration: What is the evidence?

Coluna/Columna

Denise Cantarelli Machado¹  Pedro Guarise da Silva²  Olívia Egger de Souza²  Ana Paula Lambert²  Mariana Roesch-Ely²  Asdrubal Falavigna²  Manuela Peletti-Figueiró²  João Antonio Pêgas Henriques² 

[1] Pontifícia Universidade Católica do Rio Grande do Sul;Universidade de Caxias do Sul;

关键词: Células Madre;    Degeneración del disco intervertebral;    Columna vertebral;    Células madre mesenquimales;    Disco intervertebral;   

DOI  :  10.1590/S1808-18512013000100013

来源: DOAJ

【 摘 要 】

To review the potential role of stem cells in treating degenerative disc disease of the intervertebral disc (IVD). A review was performed of articles from the Medline database concerning stem cells and degenerative disc disease (DDD). To discuss the data, the papers were classified as: review, in vitro, experimental, and clinical. The currently available treatments were basically for symptom reduction, not to revert the IVD degenerative process. The use of mesenchymal stem cells (MSC) is being proposed as an option of treatment for DDD. In vitro studies have shown that the MSC are able to differentiate into NP cells and that the MSC also reduce the inflammatory levels of the degenerated IVD. Besides, experimental studies demonstrated that the MSC remained viable when injected into the IVD, and that they were able to regenerate partially from the degenerated IVD and its structure. The few clinical studies found in the literature presented diverging results. The use of MSC is being widely studied and shows promising results for the treatment of DDD. Although many advances are being achieved in studies in vitro and experimental, there is a lack of clinical studies to prove the role of MSC in DDD management.

【 授权许可】

Unknown