The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Frontiers in Immunology

Mark R. Nicolls¹  Shirley Y. Jiang¹  Siham Arsalane¹  Wen Tian¹  Dongeon Kim¹  Xinguo Jiang¹  Shravani Pasupneti¹  Rasa Tamosiuniene²  Torrey Guan²  Norbert F. Voelkel³  Qizhi Tang⁴ 

[1] Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States;Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States;Department of Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands;Department of Surgery, University of California San Francisco, San Francisco, CA, United States;

关键词: regulatory T cell;    pulmonary arterial hypertension;    sexual dimorphism;    right ventricle;    estrogen;   

DOI  :  10.3389/fimmu.2021.684657

来源: DOAJ

【 摘 要 】

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

【 授权许可】

Unknown