Beneficial effects of Aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant status in obese rats

Journal of Functional Foods

Reda Bettioui¹  Hafida Merzouk²  Mohamed Benali³  Imad Abdelhamid El Haci⁴  Walid Rahoui⁴  Rachid Azzi⁵ 

[1] Corresponding author.;Laboratory of Biotoxicology, Department of Biology, Faculty of Natural and Life Sciences, Djilali Liabés University, Sidi Bel Abbes 22000, Algeria;Laboratory of Natural Products, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen, Algeria;Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria;Research Center on Physical and Chemical Analysis (CRAPC), BP 384, Bou-Ismail 42004, Tipaza, Algeria;

关键词: Aloe vera gel;    Adipose tissue;    Dyslipidemia;    Obesity;    Oxidative stress;   

DOI  :  

来源: DOAJ

【 摘 要 】

Natural products can be very effective in the prevention of obesity-related metabolic disorders. The aim of the present study was to investigate the anti-obesity effects of Aloe vera (Aloe barbadensis Miller) gel administration at 100 and 200 mg/kg/day, in a diet-induced obesity rat model. The whole gel was used. Plasma and tissue parameters and adipose lipase activities were determined. Our results emphasized that obese rats displayed dyslipidemia and stress oxidative, with excessive adipose tissue lipids. Aloe vera gel administration at 100 and 200 mg/kg/day prevented adipose tissue accumulation and corrected the dyslipidemia and oxidative stress. In addition, it induced adipose LPL inhibition and HSL activation in obese rats. In conclusion, Aloe vera reduced fat accumulation via its protective role against obesity-related metabolic alterations and antioxidant effects. Aloe vera has great potential as functional foods in the activation adipose lipolysis and the prevention of obesity-related metabolic alterations.

【 授权许可】

Unknown