Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment

International Journal of Molecular Sciences

Paulina Niedźwiedzka-Rystwej¹  Pedram Moeini² 

[1] Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland;Plant Virology Research Center, Shiraz University, Shiraz 71441-65186, Iran;

关键词: cancer;    macrophage;    therapeutic target;    tumor;    tumor-associated macrophage (TAM);   

DOI  :  10.3390/ijms22137239

来源: DOAJ

【 摘 要 】

Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system.

【 授权许可】

Unknown