Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

CellR4

E. Berishvili¹  M. Alibashe-Ahmed¹  T. Berney¹  L. Giovannoni¹ 

[1] Department of Surgery, Cell Isolation and Transplantation Center, University of Geneva Hospitals, Geneva, Switzerland;

关键词: type 1 diabetes;    islet transplantation;    prevention;    toll-like receptor;    tlr4;   

DOI  :  10.32113/cellr4_20205_2850

来源: DOAJ

【 摘 要 】

TLR4 is a transmembrane receptor of the innate immune system that recognize LPS of gram-negative bacteria. Its stimulation induces pro-inflammatory responses and also modulates adaptive immunity. In this article, we discuss the role of TLR4 in the activation and proliferation of T cells at the onset of autoimmune diabetes. We review the pathways involved in these observations. Finally, we show how targeting TLR4, by a variety of strategies, can prevent the occurrence of the disease but also its recurrence after allogeneic islet of Langerhans transplantation.

【 授权许可】

Unknown