Analysis of genotoxicity among subjects exposed to smoking tobacco

Hamdan Medical Journal

关键词: cytogenetics;    head-and-neck cancer;    health defects;    micronucleus;   

DOI  :  10.4103/HMJ.HMJ_47_20

来源: DOAJ

【 摘 要 】

Background: Tobacco consumption causes serious health ill-effects to human beings. Cancer and cardiovascular-related defects are more common in personal smoking. Aim & Objective: The focal aim of the present study is genetic changes in smoking subjects based on their age and exposed years. Materials and Methods: Based on the current study 80 subjects are selected from Dharmapuri district, Tamil Nadu. Fringe venous blood was gathered from both the control and the exploratory subject. Results: Increased levels of chromosomal aberration (CA) and Micronucleus (MN) are seen in heavy smokers contrasted with non-smokers separately. Both lower and light smokers indicated essentially expanded ca frequencies than control. MN indicated an expanded level of variations from the norm in smokers (light, medium, and weighty than non-smokers). Conclusion: The frequencies of MN in blood lymphocytes are high in smokers especially the heavy smoker's group demonstrated significantly increased level of genetic abnormalities.

【 授权许可】

Unknown