Therapeutic Application of Genome Editing Technologies in Viral Diseases

International Journal of Molecular Sciences

Seong-Wook Lee¹  Tae Hyeong Kim² 

[1] Department of Bioconvergence Engineering, Research Institute of Advanced Omics, Dankook University, Yongin 16890, Korea;Department of Molecular Biology, Dankook University, Cheonan 31116, Korea;

关键词: virus;    therapeutics;    genome editing;    ZFN;    TALEN;    CRISPR/Cas;   

DOI  :  10.3390/ijms23105399

来源: DOAJ

【 摘 要 】

Viral infections can be fatal and consequently, they are a serious threat to human health. Therefore, the development of vaccines and appropriate antiviral therapeutic agents is essential. Depending on the virus, it can cause an acute or a chronic infection. The characteristics of viruses can act as inhibiting factors for the development of appropriate treatment methods. Genome editing technology, including the use of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) proteins, zinc-finger nucleases (ZFNs), and transcription activator-like effector nucleases (TALENs), is a technology that can directly target and modify genomic sequences in almost all eukaryotic cells. The development of this technology has greatly expanded its applicability in life science research and gene therapy development. Research on the use of this technology to develop therapeutics for viral diseases is being conducted for various purposes, such as eliminating latent infections or providing resistance to new infections. In this review, we will look at the current status of the development of viral therapeutic agents using genome editing technology and discuss how this technology can be used as a new treatment approach for viral diseases.

【 授权许可】

Unknown