Toxicogenetics: In Search of Host Susceptibility to Environmental Toxicants

Frontiers in Genetics

Gelareh eAlam¹  Byron C Jones¹ 

[1] The Pennsylvania State University;

关键词: Systems genetics;    Genetic resources;    recombinant inbred strains;    Forward Genetic Analysis;    Reverse Genetic Analysis;   

DOI  :  10.3389/fgene.2014.00327

来源: DOAJ

【 摘 要 】

Heavy metals, various pesticide and herbicides are implicated as risk factors for human health. Paraquat, maneb, and rotenone, carbamate and organophospherous insecticides are examples of toxicants for which acute and chronic exposure are associated with multiple neurological disorders including Parkinson’s disease (PD). Nevertheless, the role of pesticide exposure in neurodegenerative diseases is not clear-cut, as there are inconsistencies in both the epidemiological and preclinical research.The aim of this short review is to show that the inconsistencies are related to individual differences in susceptibility to the effects of neurotoxicants, individual differences that can be traced to the genetic constitution of the individuals and animals studies, i.e., host-based susceptibility.

【 授权许可】

Unknown