Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

International Journal of Molecular Sciences

Guangchao Sui¹  Jinhua Wang¹  Dangdang Li¹  Jinming Shi¹  Bo Zhao¹  Juhyok Kim¹ 

[1] College of Life Science, Northeast Forestry University, Harbin 150040, China;

关键词: receptors;    natural compounds;    cancers;   

DOI  :  10.3390/ijms23052672

来源: DOAJ

【 摘 要 】

Receptors are macromolecules that transmit information regulating cell proliferation, differentiation, migration and apoptosis, play key roles in oncogenic processes and correlate with the prognoses of cancer patients. Thus, targeting receptors to constrain cancer development and progression has gained widespread interest. Small molecule compounds of natural origin have been widely used as drugs or adjuvant chemotherapeutic agents in cancer therapies due to their activities of selectively killing cancer cells, alleviating drug resistance and mitigating side effects. Meanwhile, many natural compounds, including those targeting receptors, are still under laboratory investigation for their anti-cancer activities and mechanisms. In this review, we classify the receptors by their structures and functions, illustrate the natural compounds targeting these receptors and discuss the mechanisms of their anti-cancer activities. We aim to provide primary knowledge of mechanistic regulation and clinical applications of cancer therapies through targeting deregulated receptors.

【 授权许可】

Unknown