Initial Stage of Cutaneous Primary Melanoma Plays a Key Role in the Pattern and Timing of Disease Recurrence

Acta Dermato-Venereologica

Sümeyre Seda Ertekin¹  Sebastian Podlipnik²  Cristina Carrera²  Josep Malvehy²  Alicia Barreiro-Capurro²  Constanza Riquelme-Mc Loughlin²  Susana Puig²  Ana Arance² 

[1] Department of Dermatology, Hospital Clínic of Barcelona, Barcelona, Spain. ;;

关键词: melanoma;    follow-up studies;    cutaneous malignant;    disease progression;    recurrence;    metastasis, survival;   

DOI  :  10.2340/00015555-3832

来源: DOAJ

【 摘 要 】

Given recent developments in the treatment of metastatic melanoma, early detection of disease recurrence is crucial. The aim of this single-centre retrospective cohort study was to investigate the impact of the initial stage of primary melanoma on the pattern and timing of disease recurrence and post-recurrence survival. Patients diagnosed with cutaneous melanoma with initial stage IA–IIID, between January 1996 and December 2018 and who developed disease recurrence until May 2019 were included (n = 784). Earlier stage at diagnosis was associated with a higher proportion of locoregional and a lower proportion of distant metastasis (p = 0.01). The median time to first metastasis decreased with the more advanced stages at initial diagnosis: 3.32 years (interquartile range (IQR) 1.72–6.14 years) for stage I, 1.85 years (IQR 0.99–3.78 years) for stage II and 1.19 years (IQR 0.70–2.42 years) for stage III disease (p < 0.001). These findings add evidence that American Joint Committee on Cancer stages at initial diagnosis of melanoma play a key role in the pattern and timing of disease recurrence and may be helpful to improve surveillance strategies in the follow-up of patients with melanoma.

【 授权许可】

Unknown