Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery?

Obstetrics & Gynecology Science

Kyoung-Joo Cho¹  Mi-Hyang Ko¹  Seung-Ho Lee¹  Kwang-Beom Lee¹  Soyi Lim¹  Hyun-Yee Cho² 

[1]Department of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .Korea

[2]Department of Pathology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .Korea

关键词: uterine cervical neoplasms;    hysterectomy;   

DOI  :  10.5468/ogs.2018.61.1.88

来源: DOAJ

【 摘 要 】

ObjectiveTo detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery.MethodsWe retrospectively reviewed 120 patients who underwent radical hysterectomy and pelvic lymphadenectomy as treatment for stage IB1 cervical cancer.ResultsOverall, 18 (15.0%) patients had parametrial tumor involvement. Tumor size larger than 2 cm, invasion depth greater than 1 cm, presence of lymphovascular space involvement (LVSI), corpus involvement, and positive lymph nodes were statistically associated with parametrial involvement. Multivariate analysis for other factors showed invasion depth >1 cm (P=0.029), and corpus involvement (P=0.022) were significantly associated with parametrial involvement. A subgroup with tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI.ConclusionTumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. Invasion depth >1 cm and corpus involvement were significantly associated with parametrial involvement in multivariate analysis. These finding may suggest that tumor size may a strong predictor of parametrial involvement in International Federation of Gynecology and Obstetrics stage IB1 cervical cancer, which can be used to select a subgroup population for less radical surgery.

【 授权许可】

Unknown