Microbe-Host Communication by Small RNAs in Extracellular Vesicles: Vehicles for Transkingdom RNA Transportation

International Journal of Molecular Sciences

Heon-Jin Lee¹ 

[1] Department of Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea;

关键词: microRNA (miRNA);    outer membrane vesicle (OMV);    small RNA (sRNA);    extracellular RNA (exRNA);    extracellular vesicle (EV);   

DOI  :  10.3390/ijms20061487

来源: DOAJ

【 摘 要 】

Extracellular vesicles (EVs) are evolutionary well-conserved nano-sized membranous vesicles that are secreted by both prokaryotic and eukaryotic cells. Recently, they have gained great attention for their proposed roles in cell-to-cell communication, and as biomarkers for human disease. In particular, small RNAs (sRNAs) contained within EVs have been considered as candidate interspecies-communication molecules, due to their demonstrated capacity to modulate gene expression in multiple cell types and species. While research into this field is in its infancy, elucidating the mechanisms that underlie host–microbe interactions and communications promises to impact many fields of biological research, including human health and medicine. Thus, this review discussed the results of recent studies that have examined the ways in which EVs and sRNAs mediate ‘microbe–host’ and ‘host–microbe’ interspecies communication.

【 授权许可】

Unknown