Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

Genes

Guliang Wang¹  Karen M. Vasquez¹ 

[1] Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723, USA;

关键词: non-B DNA;    genetic instability;    replication;    transcription;    collision;    DNA repair;   

DOI  :  10.3390/genes8010017

来源: DOAJ

【 摘 要 】

Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere maintenance, viral integration, transposome activation, DNA damage and repair. Thus, non-B DNA-forming sequences have been implicated in genetic instability and disease development. In this article, we discuss the interactions of non-B DNA with the replication and/or transcription machinery, particularly in disease states (e.g., tumors) that can lead to an abnormal cellular environment, and how such interactions may alter DNA replication and transcription, leading to potential conflicts at non-B DNA regions, and eventually result in genetic stability and human disease.

【 授权许可】

Unknown