Network science for the identification of novel therapeutic targets in epilepsy [version 1; referees: 2 approved]

F1000Research

Rod C. Scott¹ 

[1] Neurosciences Unit, UCL Institute of Child Health, London, UK;

关键词: Cognitive Neurology & Dementia;    Control of Gene Expression;    Developmental & Pediatric Neurology;    Epilepsy;    Medical Genetics;    Multiple Sclerosis & Related Disorders;    Neurobiology of Disease & Regeneration;    Neurodevelopment;    Neurogenetics;    Neuronal Signaling Mechanisms;    Neurorehabilitation & CNS Trauma;   

DOI  :  10.12688/f1000research.8214.1

来源: DOAJ

【 摘 要 】

The quality of life of children with epilepsy is a function of seizures and associated cognitive and behavioral comorbidities. Current treatments are not successful at stopping seizures in approximately 30% of patients despite the introduction of multiple new antiepileptic drugs over the last decade. In addition, modification of seizures has only a modest impact on the comorbidities. Therefore, novel approaches to identify therapeutic targets that improve seizures and comorbidities are urgently required. The potential of network science as applied to genetic, local neural network, and global brain data is reviewed. Several examples of possible new therapeutic approaches defined using novel network tools are highlighted. Further study to translate the findings into clinical practice is now required.

【 授权许可】

Unknown