Soluble CD163-Associated Dietary Patterns and the Risk of Metabolic Syndrome

Nutrients

Chyi-Huey Bai¹  Nindy Sabrina²  AlexeyA. Tinkov³  AnatolyV. Skalny³  Tzu-Yu Hu⁴  Jung-Su Chang⁴  Shin-Yng Lee⁴  Meng-Jung Chou⁴  Meng-Chieh Wu⁴  Chun-Kuang Shih⁴  I-Chun Teng⁴ 

[1] Department of Public Health, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan;Nutrition Program, Faculty of Food Technology and Health, Sahid Jakarta University, Jakarta 12870, Indonesia;Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya St., 6, Moscow 105064, Russia;School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan;

关键词: soluble CD163;    dietary pattern;    AST;    red blood cell aggregation;    metabolic syndrome;    obesity;   

DOI  :  10.3390/nu11040940

来源: DOAJ

【 摘 要 】

Elevated soluble cluster of differentiation 163 (sCD163) concentrations, a marker of macrophage activation, are associated with obesity. Weight reduction decreases circulating CD163 levels, and changes in sCD163 levels are associated with improved metabolic dysfunction. Currently, the relationship between sCD163 and diet remains unclear. This study investigated dietary patterns associated with sCD163 concentrations and its predictive effect on metabolic syndrome (MetS). Data on anthropometrics, blood biochemistry, and a food frequency questionnaire were collected from 166 Taiwanese adults. sCD163 levels independently predicted MetS (odds ratio (OR): 5.35; 95% confidence interval (CI): 2.13~13.44, p < 0.001), non-alcoholic fatty liver disease (OR: 2.19; 95% CI: 1.03~4.64, p < 0.001), and central obesity (OR: 3.90; 95% CI: 1.78~8.55, p < 0.001), after adjusting for age and sex. An adjusted linear regression analysis revealed strong correlations between levels of sCD163 and aspartate transaminase (AST) (β = 0.250 (0.023~0.477), p < 0.05) and red blood cell aggregation (β = 0.332 (0.035~0.628), p < 0.05). sCD163-associated dietary pattern scores (high frequencies of consuming noodles and desserts, and eating at home, and a low intake frequency of steamed/boiled/raw food, white/light-green-colored vegetables, orange/red/purple-colored vegetables, dairy products, seafood, dark-green leafy vegetables, and soy products) were positively correlated with MetS, liver injury biomarkers, and sCD163 levels (all p for trend < 0.05). Individuals with the highest dietary pattern scores (tertile 3) had a 2.37-fold [OR: 2.37; 95% CI: 1.04~5.37, p < 0.05] higher risk of MetS compared to those with the lowest scores (tertile 1). Overall, the study findings suggest the importance of a healthy dietary pattern in preventing elevated sCD163 levels and diet-related chronic disease such as MetS.

【 授权许可】

Unknown