Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension

Molecules

Anna Jastrząb¹  Hanna Kozłowska²  Marta Baranowska-Kuczko²  Anna Krzyżewska²  Irena Kasacka³ 

[1] Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicz 2D, 15-222 Bialystok, Poland;Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicz 2A, 15-222 Bialystok, Poland;Department of Histology and Cytophysiology, Medical University of Bialystok, Mickiewicz 2C, 15-222 Bialystok, Poland;

关键词: pulmonary hypertension;    cannabidiol;    oxidative stress;    inflammation;    monocrotaline;   

DOI  :  10.3390/molecules27103327

来源: DOAJ

【 摘 要 】

Cannabidiol (CBD) is a plant-derived compound with antioxidant and anti-inflammatory properties. Pulmonary hypertension (PH) is still an incurable disease. CBD has been suggested to ameliorate monocrotaline (MCT)-induced PH, including reduction in right ventricular systolic pressure (RVSP), a vasorelaxant effect on pulmonary arteries and a decrease in the white blood cell count. The aim of our study was to investigate the effect of chronic administration of CBD (10 mg/kg daily for 21 days) on the parameters of oxidative stress and inflammation in the lungs of rats with MCT-induced PH. In MCT-induced PH, we found a decrease in total antioxidant capacity (TAC) and glutathione level (GSH), an increase in inflammatory parameters, e.g., tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), nuclear factor kappa B (NF-κB), monocyte chemoattractant protein-1 (MCP-1), and cluster of differentiation 68 (CD68), and the overexpression of cannabinoid receptors type 1 and 2 (CB₁-Rs, CB₂-Rs). Administration of CBD increased TAC and GSH concentrations, glutathione reductase (GSR) activity, and decreased CB₁-Rs expression and levels of inflammatory mediators such as TNF-α, IL -1β, NF-κB, MCP-1 and CD68. In conclusion, CBD has antioxidant and anti-inflammatory effects in MCT-induced PH. CBD may act as an adjuvant therapy for PH, but further detailed preclinical and clinical studies are recommended to confirm our promising results.

【 授权许可】

Unknown