Lactobacillus fermentum Stimulates Intestinal Secretion of Immunoglobulin A in an Individual-Specific Manner

Foods

Jian Lu¹  Hao Zhang²  Gang Wang²  Jialiang Wang²  Wei Chen²  Jianxin Zhao²  Liya Mei²  Ying Chen² 

[1] Department of Gastroenterology, Affiliated Wuxi No. 2 People’s Hospital of Nanjing Medical University, Wuxi 214122, China;State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China;

关键词: probiotics;    Immunoglobulin A;    immunity;    gut microbiota;    Immunoglobulin A-coated bacteria;   

DOI  :  10.3390/foods11091229

来源: DOAJ

【 摘 要 】

Immunoglobulin A (IgA), as the most secreted immunoglobulin in the intestine, plays an irreplaceable role in mucosal immunity regulation. Previous studies have indicated that Lactobacillus showed strain specificity in stimulating the secretion of IgA through intestinal mucosal lymphocytes. The reason for this phenomenon is not clear. The current studies have been aimed at exploring the effect of a strain on the secretion of IgA in the host’s intestine, but the mechanism behind it has not been seriously studied. Based on this, we selected five strains of Lactobacillus fermentum isolated from different individuals to determine whether there are intraspecific differences in stimulating the secretion of IgA from the intestinal mucosa. It was found that IgA concentrations in different intestinal segments and faeces induced by L. fermentum were different. 12-1 and X6L1 strains increased the secretion of IgA by the intestine significantly. In addition, different strains of L. fermentum were also proven to have different effects on the host gut microbiota but no significant effects on IgA-coated microbiota. Besides, it was speculated that different strains of L. fermentum may act on different pathways to stimulate IgA in a non-inflammatory manner. By explaining the differences of IgA secretion in the host’s intestine tract stimulated by different strains of L. fermentum, it is expected to provide a theoretical basis for the stimulation of intestinal secretion of IgA by Lactobacillus and a new direction for exploring the relationship between Lactobacillus and human immunity.

【 授权许可】

Unknown