Anti-dsDNA Antibodies are one of the many autoantibodies in systemic lupus erythematosus [version 1; referees: 2 approved]

F1000Research

Zhenhuan Zhao¹  Chao Dai¹  Shu Man Fu²  Felicia Gaskin³ 

[1] Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, Box 800133, Charlottesville, VA, 22908-0133, USA;Department of Microbiology, Immunology and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA;Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA;

关键词: Autoimmunity;    Etiology, Pathogenesis & Animal Models of Rheumatic Disease;    Immune & Inflammatory Rheumatic Diseases (incl. Arthritis);    Immunological Biomarkers;   

DOI  :  10.12688/f1000research.6875.1

来源: DOAJ

【 摘 要 】

Anti-dsDNA antibodies are the most studied antibodies of the lupus-related autoantibodies. The dogma is that these are the most important autoantibodies in systemic lupus erythematosus. In this review, evidence is presented to show that these antibodies (as measured by modern clinical laboratories) are not the most important autoantibodies in the diagnosis of systemic lupus erythematosus, and are of limited value in clinical correlation and in predicting disease flares. In addition, they are not likely to be the initiating autoantibodies in lupus nephritis. Thus, several pervasively held beliefs on anti-dsDNA antibodies are not valid. We suggest that anti-dsDNA antibodies should be considered as just one of the many autoantibodies associated with systemic lupus erythematosus.

【 授权许可】

Unknown