SARS-CoV-2 Infection Triggers Auto-Immune Response in ARDS

Frontiers in Immunology

Javier De Las Rivas²  Quentin Lecrevisse⁵  Alicia Landeira-Viñuela⁵  Marina L. García-Vaquero⁵  Rafael Góngora⁵  Pablo Juanes-Velasco⁵  Antonio Ferruelo⁷  Raquel Herrero⁷  Jose A. Lorente⁷  Fernando Corrales⁸  Manuel Fuentes⁸  Ángela-Patricia Hernández⁹ 

[1] University of Salamanca, Salamanca, Spain;;Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Científicas &CIBER de Enfermedades Respiratorias, Instituto de Investigación Carlos III, Madrid, Spain;Department of Critical Care Medicine, Hospital Universitario de Getafe, Madrid, Spain;Department of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain;Functional Proteomics Laboratory, National Center for Biotechnology, Consejo Superior de Investigaciones Científicas, Madrid, Spain;Fundación de Investigación Biomédica del Hospital Universitario de Getafe, Madrid, Spain;PROTEORED-ISCIII, Red Nacional de Laboratorios de Proteomica-ISCIII, Madrid, Spain;Universidad Europea de Madrid, Madrid, Spain;

关键词: SARS-CoV-2;    COVID-19;    ARDS;    auto-antibodies;    antigen;    acute-phase proteins;   

DOI  :  10.3389/fimmu.2022.732197

来源: DOAJ

【 摘 要 】

Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients’ profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients.

【 授权许可】

Unknown