Anticancer activity, spectroscopic and molecular docking of some new synthesized sugar hydrazones, Arylidene and α-Aminophosphonate derivatives

Arabian Journal of Chemistry

Amer H. Trawneh¹  Ahmed M. Metwaly²  Hamada H. Amer³  Saad H. Alotaibi³  Ibrahim H. Eissa⁴ 

[1] Corresponding author at: Department of Chemistry, Turabah University College, Turabah, Taif University, 21995, Saudi Arabia.;Chemistry and Chemical Technology Department, Faculty of Science, Tafila Technical University, Tafila 61610, Jordan;Department of Chemistry, Turabah University College, Turabah, Taif University, Saudi Arabia;Pharmacognosy Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt;

关键词: 4-Hydroxybenzaldehyde;    Nucleosides;    Arylidene derivatives;    Molecular docking;    Anticancer agents;   

DOI  :  

来源: DOAJ

【 摘 要 】

In this work, we design and then synthesis of new derivatives of nucleosides, oxadiazoline derivatives containing acetylated sugars and α-aminophosphonate derivatives. The synthesized compounds have been elucidated by different spectroscopic analysis, such as, elemental analysis, 13C NMR, infrared (IR) and 1H NMR. The compounds previously synthesized were purified and then tested against breast cancer cells (MCF-7). The results showed that the compounds 5d, 6b, 7a and 9h showed moderate to very high activity against breast cancer, with incidence rates of 78.45%, 84.60%, 93.45% and 95.78%, respectively. The reference ratio of 5-fluorouracil was inhibitory of 96.02%. The binding potential of synthesized compounds against thymidylate synthase (TS) and Cathepsin B (CB) has been investigated and the compounds 7a and 9h exhibits highly binding with thymidylate synthase (TS) and Cathepsin B (CB).

【 授权许可】

Unknown