In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives

Journal of Taibah University for Science

Talha jawaid¹  Aftab Alam²  Pravej Alam³ 

[1] College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU);College of Pharmacy, Prince Sattam Bin Abdulaziz University;College of Science and Humanities, Prince Sattam Bin Abdulaziz University;

关键词: guatemala cardamom;    essential oil;    chemical composition;    antioxidant;    anti-inflammatory;    in silico study;   

DOI  :  10.1080/16583655.2021.2002550

来源: DOAJ

【 摘 要 】

Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential oil (GCEO) was extracted using hydro-distillation method, and analyzed using gaschromatography/ mass-spectrometry (GC-MS). The antioxidant and anti-inflammatory activities were studied using 2,2-diphenyl-1-picrylhydrazyl-hydrate, ferric-chloride, bovine serum-albumin and proteinase inhibitory assays. GC-MS results confirmed the presence of α- terpinyl acetate and 1,8-cineole as major components. The antioxidant and anti-inflammatory activities of GCEO were found to be significant compared with those of standard ascorbic acid and ibuprofen, respectively. The molecular-docking study revealed the considerable binding potential of α-terpinyl acetate and 1,8-cineole with human-peroxiredoxin-5, tyrosine-kinases and Human-5-LOX receptors. The in-silico activity prediction analysis confirmed the antioxidant and anti-inflammatory potential, whereas the pharmacokinetics confirmed the safety of most of the GCEO compounds.

【 授权许可】

Unknown