Effect of PI3K/AKT Pathway on Cisplatin Resistance in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer

Gang XU¹  Yu ZHANG¹  Hongling LU² 

[1] Departmen of Cardiothoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563099, China;Department of Biochemistry, Zunyi Medical College, Zunyi 563099, China;

关键词: Lung neoplasms;    PI3k/AKT pathway;    Cisplatin;    Resistance;    Molecular mechanisms;   

DOI  :  10.3779/j.issn.1009-3419.2014.08.09

来源: DOAJ

【 摘 要 】

Accumulating evidences indicate that aberrant activation of PI3K/AKT pathway in non-small cell lung cancer plays a vital role in tumor cell proliferation,apoptosis, and survival including drug resistance. Cisplatin as first-line chemotherapy are in widespread clinical use in patients with non-small cell lung cancer, however, the development of cisplatin resistance significantly impedes its clinic efficacy. Cisplatin resistance is a complicated process that various mechanisms participating in to interact, of which PI3K/AKT pathway keeping sustained activated is one of the most important reasons. This article reviewed the progress of research on the relationship between PI3K/AKT pathway and cisplatin resistance.

【 授权许可】

Unknown