Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke

Life

Isabel Silva¹  Luís F. Maia¹  Alexandre Dias¹  Inês Mendes Pinto² 

[1] Department of Neurology, Centro Hospitalar Universitário do Porto (CHUPorto), 4099-001 Porto, Portugal;International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal;

关键词: stroke;    biomarkers;    blood;    POC devices;    biosensors;   

DOI  :  10.3390/life11080816

来源: DOAJ

【 摘 要 】

Stroke is a leading cause of death and disability in the world. To address such a problem, early diagnosis and tailored acute treatment represent one of the major priorities in acute stroke care. Since the efficacy of reperfusion treatments is highly time-dependent, there is a critical need to optimize procedures for faster and more precise diagnosis. We provide a concise review of the most relevant and well-documented blood–protein biomarkers that exhibit greater potential for translational to clinical practice in stroke differential diagnosis and to differentiate ischemic stroke from hemorrhagic stroke, followed by an overview of the most recent point-of-care technological approaches to address this problem. The integration of fluid-based biomarker profiling, using point-of-care biosensors with demographic, clinical, and neuroimaging parameters in multi-dimensional clinical decision-making algorithms, will be the next step in personalized stroke care.

【 授权许可】

Unknown