Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy

Journal of Nanobiotechnology

Jing Hu¹  Lingxiao Zhang²  Huina Liu²  Ting Cai²  Shun Zhang² 

[1] Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University;Ningbo Clinical Research Center for Digestive System Tumors, Ningbo Hwa Mei Hospital, University of Chinese Academy of Sciences;

关键词: Nanovaccine;    Cancer immunotherapy;    Lymphoid organ;    Vaccine delivery;    Immune barrier;   

DOI  :  10.1186/s12951-021-01146-2

来源: DOAJ

【 摘 要 】

Abstract With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit limiting the rapid induction of anti-tumor immune response. Unlike the conventional prophylactic vaccines that mainly form a depot at the injection site to gradually trigger durable immune response, the rapid proliferation of tumors requires an efficient delivery of nanovaccines to lymphoid organs for rapid induction of anti-tumor immunity. Optimization of the physicochemical properties of nanovaccine (e.g., size, shape, charge, colloidal stability and surface ligands) is an effective strategy to enhance their accumulation in lymphoid organs, and nanovaccines with dynamic structures are also designed for precise targeted delivery of lymphoid organs or their subregions. The recent progress of these nanovaccine delivery strategies is highlighted in this review, and the challenges and future direction are also discussed. Graphical Abstract

【 授权许可】

Unknown