Non-compliance to iron chelation therapy in patients with transfusion-dependent thalassaemia

Pediatric Hematology Oncology Journal

Siti Suhaila Mohd Yusoff¹  Nani Draman²  Allen Shiun Chat Chai²  Nurul Fatihah Azman²  Najib Majdi Yaacob²  Bin Alwi Zilfalil³  Wan Zaidah Abdullah³  Rosline Hassan⁴  Maryam Mohd Zulkifli⁵  Norsarwany Mohamad⁶ 

[1] Corresponding author.;Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia;Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia;Department of Pediatrics, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia;Malaysian Node of the Human Variome Project, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia;Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia;

关键词: Non-compliance;    Iron chelation therapy;    Transfusion-dependent thalassaemia;    Social support;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim: To determine the proportion of non-compliance to iron chelation therapy (ICT) and its associated factors amongst patients with transfusion-dependent thalassaemia (TDT) in Malaysia. Methods: A cross-sectional study was conducted amongst patients with TDT aged 9 years old and above, who were on iron chelation treatment, attending three tertiary hospitals in Kelantan and Terengganu. The socio-demographic, clinical and chelator history of patients were obtained. The compliance of patients to chelators was assessed using the Medication Compliance Questionnaire (MCQ). Social support was assessed using the Medical Outcome Study–Social Support Survey (MOS). Data was analysed using simple and multiple logistic regression. Results: The proportion of non-compliance to ICT was 24.7%. Age, activity restriction and latest serum ferritin level of ≥1000 μg/L were significantly associated with non-compliance to ICT. Conclusion: The non-compliance to ICT amongst patients with TDT in Kelantan and Terengganu is 24.7%. Providing motivational interview, enhanced self-empowerment of patients and psychological support are recommended to improve the non-compliance aspect amongst patients on ICT.

【 授权许可】

Unknown