Research advances in the influence of hepatic stellate cells on precancerous lesions of liver cirrhosis and hepatocellular carcinoma via the TGFβ1-PI3K/AKT signaling pathway

Linchuang Gandanbing Zazhi

JU Di¹ 

[1] Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China;

关键词: liver cirrhosis;    carcinoma;    hepatocellular;    precancerous conditions;    hepatic stellate cell;    signal transduction;    review;   

DOI  :  10.3969/j.issn.1001-5256.2018.01.042

来源: DOAJ

【 摘 要 】

The malignant transformation of the precancerous lesions of liver cirrhosis and hepatocellular carcinoma (HCC) leads to the formation of liver cancer. Hepatic stellate cells (HSCs) play a role in the production of cells in precancerous lesions of HCC, the formation of hepatic fibrosis microenvironment, and the interaction between them via the TGFβ1-PI3K/AKT signaling pathway. An understanding of the mechanism for the malignant transformation of the precancerous lesions of liver cirrhosis and HCC and the association between HSCs and the TGFβ1-PI3K/AKT signaling pathway helps to investigate the pathogenesis of HCC. Regulation of HSCs or intervention of the TGFβ1-PI3K/AKT signaling pathway can inhibit or reverse the progression of liver cirrhosis to HCC, which provides new thoughts and therapeutic targets for prevention and intervention of the development of HCC.

【 授权许可】

Unknown