Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Frontiers in Neurology

Jian-yi Huang¹  Teng Long¹  Hong-yu Lin¹  Ning-chao Liang¹  Qing-qing Wei¹  Xing-hua Pan¹  Cai-xia Huang¹  Wen Gao²  Sheng-liang Shi³ 

[1] Department of Neurology, People's Hospital of Chongzuo City, Chongzuo, China;Department of Neurology, People's Hospital of Liuzhou City, Liuzhou, China;Department of Neurology, Second Affiliated Hospital of Guangxi Medical University, Nanning, China;

关键词: intracerebral hemorrhage;    outcome;    mortality;    seizures;    systematic review;    meta-analysis;   

DOI  :  10.3389/fneur.2022.922677

来源: DOAJ

【 摘 要 】

BackgroundThe relationship between mortality and seizures after intracerebral hemorrhage (ICH) has not yet been understood until now. A meta-analysis was performed to assess the effect of post-ICH seizures on mortality among patients with ICH.MethodsPubMed and Embase were searched from the establishment of the databases to December 2021 to identify literature that evaluated the relationship between post-ICH seizures and mortality in ICH. Crude odds ratios and adjusted odds ratios with a 95% confidence interval (CI) were pooled using a random-effects model.ResultsThirteen studies involving 245,908 participants were eventually included for analysis. The pooled estimate suggested that post-ICH seizures were not associated with significantly increased mortality in patients with ICH (crude odds ratios 1.35, 95% CI: 0.91–2; adjusted adds ratios 1.22, 95% CI: 0.78–1.88). However, the relationship was not consistent in subgroup analysis or robust in a sensitivity analysis.ConclusionsThis meta-analysis proved that post-ICH seizures were not associated with significantly increased mortality in patients with ICH. However, this result could be influenced by confounding factors, so more high-quality research is needed.

【 授权许可】

Unknown