Comparison of human papillomavirus (HPV) detection in urine and cervical swab samples using the HPV GenoArray Diagnostic assay

PeerJ

Yong Poovorawan¹  Pornjarim Nilyanimit¹  Jira Chansaenroj¹  Piyawat Laowahutanont²  Anant Karalak³  Pairoj Junyangdikul⁴ 

[1] Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;Department of Gynecology, National Cancer Institute, Bangkok, Thailand;Department of Pathology, National Cancer Institute, Bangkok, Thailand;Department of Pathology, Samitivej Srinakarin Hospital, Bangkok Hospital Group, Bangkok, Thailand;

关键词: HPV;    Urine;    Genotyping;    Cervical cancer;   

DOI  :  10.7717/peerj.3910

来源: DOAJ

【 摘 要 】

Human papillomavirus (HPV) is the leading cause of cervical cancer. Urine-based HPV testing offers a simple and non-invasive method because of its increasing acceptance. A total of 164 pairs of cervical swab and urine samples from Thai women who underwent cervical cancer screening were used for HPV testing with HPV GenoArray Diagnostic Kits. The overall concordance percentage for HPV detection in the cervical swab and urine samples was 65.2%. The HPV genotypes most commonly detected were HPV16 and HPV18. An analysis of the urine samples and a second analysis of the cervical swab samples showed that the differences in the overall HPV detection rate between women with normal and abnormal cytology were not significant (p > 0.05). Urine samples processed with the GenoArray assay is an alternative for women who decline to undergo Pap smear even though it is not ideal as the first-line screening option.

【 授权许可】

Unknown