Safety and Efficacy of Personalized Cancer Vaccines in Combination With Immune Checkpoint Inhibitors in Cancer Treatment

Frontiers in Oncology

Juan-Yan Liao²  Shuang Zhang² 

[1] Department of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, China;Sichuan Clinical Research Center of Biotherapy, Chengdu, China;

关键词: personalized cancer vaccine;    immune checkpoint inhibitor;    combination therapy;    neoantigen;    immunotherapy;   

DOI  :  10.3389/fonc.2021.663264

来源: DOAJ

【 摘 要 】

Cancer immunotherapy can induce sustained responses in patients with cancers in a broad range of tissues, however, these treatments require the optimized combined therapeutic strategies. Despite immune checkpoint inhibitors (ICIs) have lasting clinical benefit, researchers are trying to combine them with other treatment modalities, and among them the combination with personalized cancer vaccines is attractive. Neoantigens, arising from mutations in cancer cells, can elicit strong immune response without central tolerance and out-target effects, which is a truly personalized method. Growing studies show that the combination can elevate the antitumor efficacy with acceptable safety and minimal additional toxicity compared with single agent vaccine or ICI. Herein, we have searched these preclinical and clinical trials and summarized safety and efficacy of personalized cancer vaccines combined with ICIs in several malignancies. Meanwhile, we discuss the rationale of the combination and future challenges.

【 授权许可】

Unknown