Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex

Cell Reports

Jessica Kelemen¹  Jad Saab²  Leigh R. Hochberg²  Beata Jarosiewicz³  Eric Halgren⁴  Sydney S. Cash⁵  Jean-Baptiste Eichenlaub⁶  Brian Franco⁷ 

[1] Carney Institute for Brain Science, Brown University, Providence, RI, USA;Corresponding author;Department of Neurology, Harvard Medical School, Boston, MA, USA;VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of VA Medical Center, Providence, RI, USA;Carney Institute for Brain Science, Brown University, Providence, RI, USA;Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA;Department of Neuroscience, Brown University, Providence, RI, USA;

关键词: memory;    replay;    learning;    consolidation;    reactivation;    human;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: The offline “replay” of neural firing patterns underlying waking experience, previously observed in non-human animals, is thought to be a mechanism for memory consolidation. Here, we test for replay in the human brain by recording spiking activity from the motor cortex of two participants who had intracortical microelectrode arrays placed chronically as part of a brain-computer interface pilot clinical trial. Participants took a nap before and after playing a neurally controlled sequence-copying game that consists of many repetitions of one “repeated” sequence sparsely interleaved with varying “control” sequences. Both participants performed repeated sequences more accurately than control sequences, consistent with learning. We compare the firing rate patterns that caused the cursor movements when performing each sequence to firing rate patterns throughout both rest periods. Correlations with repeated sequences increase more from pre- to post-task rest than do correlations with control sequences, providing direct evidence of learning-related replay in the human brain.

【 授权许可】

Unknown