Tenofovir prophylaxis for preventing mother-to-child hepatitis B virus transmission in China: A cost-effectiveness analysis

International Journal of Infectious Diseases

Gang Chen¹  Xiaofeng Liang²  Fuzhen Wang²  Guihua Zhuang³  Peifeng Liang⁴  Juan Yin⁵  Fuqiang Cui⁶ 

[1] Centre for Health Economics, Monash Business School, Monash University, Clayton, Victoria, Australia;Chinese Center for Disease Control and Prevention, Beijing, China;Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, China;Department of Medical Statistics, Ningxia Hui Autonomous Region People's Hospital, Yinchuan, Ningxia, China;Nursing Faculty, School of Medicine, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, China;Peking University Health Science Center, Beijing, China;

关键词: Tenofovir;    Hepatitis B;    Quality-adjusted life years;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: This study aimed to evaluate whether tenofovir prophylaxis for mothers with high viral loads in late pregnancy is a cost-effective way to prevent mother-to-child hepatitis B virus (HBV) transmission in China. Methods: A decision tree Markov model was constructed for a cohort of infants born to HBV surface antigen-positive mothers in China, 2016. The expected cost and effectiveness were compared between the current active-passive immunoprophylaxis strategy and the tenofovir prophylaxis strategy, and the incremental cost-effectiveness ratio was calculated. One-way and multi-way probabilistic sensitivity analyses were performed. Results: For 100,000 babies born to mothers positive for hepatitis B surface antigen, tenofovir prophylaxis strategy will prevent 2213 perinatal HBV infections and will gain 931 quality-adjusted life years when compared with the current active-passive immunoprophylaxis strategy. The incremental cost-effectiveness ratio was ￥59,973 ($9087) per quality-adjusted life years gained. This result was robust over a wide range of assumptions. Conclusions: Tenofovir prophylaxis for mothers with high viral loads in late pregnancy was found to be more cost-effective than the current active-passive immunoprophylaxis alone. Embedding tenofovir prophylaxis for mothers with high virus loads into the present hepatitis B prevention strategies should be considered to further prevent mother-to-child hepatitis B transmission in China.

【 授权许可】

Unknown