Cholecystectomy Damages Aging-Associated Intestinal Microbiota Construction

Frontiers in Microbiology

Julan Li¹  Qiang Guo¹  Junfeng Wang²  Yun Jin²  Pingping Yan³  Jiawei Geng³  Ruyi Zhang³  Wei Yue³  Wenxue Wang⁴ 

[1] Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, China;Department of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunming, China;Department of Infectious Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China;Kunming University of Science and Technology, Kunming, China;

关键词: cholecystectomy;    intestinal bacteria;    colorectal cancer;    aging;    bile acids;   

DOI  :  10.3389/fmicb.2018.01402

来源: DOAJ

【 摘 要 】

The intestinal microbiome is essential in humans to maintain physiological balance and nutrition metabolism. Laparoscopic cholecystectomy due to gallstone disease and cholecystitis can cause intestinal microbial dysbiosis, and following bile acid metabolism dysfunction, positions the patient at high risk of colorectal cancer. However, little is known regarding intestinal microbiota characteristics in post-cholecystectomy patients. Here, we compared the microbial composition of cholecystectomy patients with that of a healthy population. We determined that cholecystectomy eliminated aging-associated fecal commensal microbiota and further identified several bile acid metabolism-related bacteria as contributors of colorectal cancer incidence via elevation of secondary bile acids.Significance statementWe identified aging-associated fecal microbiota in a healthy population, which was lost in cholecystectomy patients. Absent intestinal bacteria, such as Bacteroides, were negatively related to secondary bile acids and may be a leading cause of colorectal cancer incidence in cholecystectomy patients. Our study provides novel insight into the connection between cholecystectomy-altered gut microbiota and colorectal carcinoma, which is of value for colorectal cancer diagnosis and management.

【 授权许可】

Unknown