Regorafenib-induced renal-limited thrombotic microangiopathy: a case report and review of literatures

BMC Nephrology

Song Lei¹  Huan Xu¹  Ping Fu²  Qinghua Yin²  Hui Zhong²  Na Guo²  Xueli Zhou² 

[1] Department of Pathology, West China Hospital, Sichuan University;Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University;

关键词: Nephrotic syndrome;    Regorafenib;    Thrombotic microangiopathy (TMA);    Tyrosine kinase inhibitors (TKI);    Case report;   

DOI  :  10.1186/s12882-021-02656-9

来源: DOAJ

【 摘 要 】

Abstract Background Regorafenib belongs to a sub-group of small-molecule multi-targeted tyrosine kinase inhibitors(TKIs). In various studies with respect to the side-effect of regorafenib, drug-associated proteinuria standardly qualified to be defined as nephrotic syndrome was rarely reported as well as the relation of regorafenib with the occurrence and development of thrombotic microangiopathy (TMA). Case presentation In this case report and literature review, we presented a 62-year-old patient receiving regorafenib for metastatic colon cancer, manifesting abundant proteinuria, in which TMA was also diagnosed through renal biopsy. As far as we were concerned, this was the first reported in terms of regorafenib-induced TMA confirmed by renal biopsy. Conclusion This case indicates that regorafenib, a kind of TKIs may result in TMA, which is a rare but life-threatening complication of cancer treatment drug. Insights from this case might help physicians diagnose rare forms of TMA and adjust treatment for patients in a timely manner.

【 授权许可】

Unknown