Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia

Endocrines

Maria Rinzivillo¹  Francesco Panzuto¹  Ludovica Magi² 

[1] Digestive Disease Unit, Sant’Andrea University Hospital—ENETS Center of Excellence of Via di Grottarossa, 1035, 00189 Rome, Italy;SAIMLAL Department (Human Anatomy, Histology, Forensic Medicine and Orthopedics), Sapienza University of Rome, 00185 Rome, Italy;

关键词: neuroendocrine tumors;    Ki67;    carcinoids;    somatostatin analogs;    radiomic;    positron emission tomography;   

DOI  :  10.3390/endocrines2010003

来源: DOAJ

【 摘 要 】

Owing to the rarity and the biological and clinical heterogeneity of gastroenteropancreatic neuroendocrine neoplasia (GEP NEN), the management of these patients may be challenging for physicians. This review highlights the specific features of GEP NEN with particular attention on the role of Ki67 heterogeneity, the potential prognostic role of novel radiological techniques, and the clinical usefulness of functional imaging, including 68Ga-DOTA-SST PET/CT and 18F-FDG PET/CT. Understanding these specific features may help to plan proper and tailored follow-up programs and therapeutic approaches.

【 授权许可】

Unknown