Glucose patterns following alcohol and illicit drug use in young adults with type 1 diabetes: A flash glucose monitoring study

Endocrinology, Diabetes & Metabolism

Yvonne Bonomo¹  Adam Pastor¹  Lisa Collins¹  Margaret Loh²  Jessie Teng²  Richard J MacIsaac³  Jennifer Conn³  Casey L O'Brien⁴  Sue Finch⁵ 

[1] Department of Addiction Medicine St Vincent's Hospital Melbourne Fitzroy Vic. Australia;Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne Fitzroy Vic. Australia;Department of Medicine University of Melbourne Parkville Vic. Australia;Mental Health Services St Vincent's Hospital Melbourne Fitzroy Vic. Australia;School of Mathematics and Statistics University of Melbourne Parkville Vic. Australia;

关键词: alcohol drinking;    diabetes;    diabetes mellitus;    harm reduction;    health behaviour;    interventions;   

DOI  :  10.1002/edm2.257

来源: DOAJ

【 摘 要 】

Abstract Introduction To assess the effects of alcohol and illicit drug use in young adults (age 18–35) with type 1 diabetes (T1D) on flash glucose monitor sensor glucose (SG) readings. Methods Twenty young adults with T1D were enrolled from a tertiary referral hospital outpatient department in Melbourne, Australia for a 6‐week prospective observational study using flash glucose monitoring (FGM). Glucometrics comparing substance using days (SUEDs) to those without substance use (non‐SUEDS) were analysed. The primary outcomes were the difference in mean SG values, its standard deviation and minutes/24‐h period out of range (SG <3.9 mmol/L or >10.0 mmol/L) between matched SUEDs vs non‐SUEDs. An interaction model with the primary effect of HbA1c on SG values was also performed. Results There were no differences in the primary outcome measures between SUEDS and non‐SUEDs. However, there were differences in the regression coefficients for HbA1c and glucometrics between non‐SUEDs and SUEDs for mean SG, time out of range and time with SG > 10 mmol/L. This difference was also identified between non‐SUEDS and days of ≥40 g alcohol for mean SG. Conclusions While there was no difference between glucometrics for SUEDs and non‐SUEDs on primary outcomes, HbA1C was found to be a less reliable predictor of glucose patterns in the 24‐h period following substance use than control days. Young adults with T1D need to monitor and respond to their glucose levels following substance use and engage in harm minimisation practices irrespective of baseline glucose control.

【 授权许可】

Unknown