Prognostic and clinicopathologic significance of long non-coding RNA opa-interacting protein 5-antisense RNA 1 in multiple human cancers

Artificial Cells, Nanomedicine, and Biotechnology

Jieyu He¹  Wanchun Wang²  Xiaolei Ren²  Zhixi Duan²  Chenghao Zhang²  Zhihong Li²  Shuangqing Li²  Lin Qi²  Chao Tu² 

[1] Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China;Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China;

关键词: LncRNA;    OIP5-AS1;    cancer;    osteosarcoma;    biomarker;   

DOI  :  10.1080/21691401.2019.1709854

来源: DOAJ

【 摘 要 】

Background OIP5-AS1 has been reported to be aberrantly expressed in multiple cancers and associated with clinical outcomes. We conducted this study to assess the generalized prognostic value of OIP5-AS1 in cancers.Methods PubMed, Web of science, and Cochrane Library were searched for eligible studies. Hazards ratios (HRs) or odd ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic value of OIP5-AS1 in cancers, including overall survival (OS), age, gender, tumor size, clinical stage, and lymph node metastasis (LNM). Publication bias was measured by Begg’s test and funnel plot. Sensitivity analysis were used to detect the stability of pooled results.Results Overall, eleven studies containing 713 patients were eventually enrolled. The pooled results showed that high OIP5-AS1 expression was correlated with shorter OS (HR = 0.48, 95%CI: 0.35–0.64), regardless of the sample size, tumor type and follow-up time. Furthermore, elevated expression of OIP5-AS1 indicated advanced clinical stage (OR = 2.12, 95% CI: 1.06–4.23), but not associated with age, gender, tumor size and LNM. No publication bias was detected.Conclusion High expression of lncRNA OIP5-AS1 may predict a poor OS and advanced clinical stage, implicating that OIP5-AS1 may be a possible prognostic factor in cancers.

【 授权许可】

Unknown