Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design

Journal of Pharmacy and Bioallied Sciences

关键词: Pullulan;    central composite experimental design;   

DOI  :  10.4103/0975-7406.94150

来源: DOAJ

【 摘 要 】

The objective of this work was to apply central composite experimental design to investigate main and interaction effect of formulation parameters in optimizing novel fast disintegration tablets formulation using pullulan as diluents. Face centered central composite experimental design was employed to optimize fast disintegration tablet formulation. The variables studied were concentration of diluents (pullulan, X1), superdisintigrant (sodium starch glycolate, X2), and direct compression aid (spray dried lactose, X3). Tablets were characterized for weight variation, thickness, disintegration time (Y1) and hardness (Y2). Good correlation between the predicted values and experimental data of the optimized formulation methodology in optimizing fast disintegrating tablets using pullulan as a diluent.

【 授权许可】

Unknown