Hydrogel Biomaterials for Stem Cell Microencapsulation

Polymers

Hansoo Park¹  Junha Park²  Goeun Choe²  JaeYoung Lee² 

[1] School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea;School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea;

关键词: hydrogel;    stem cell;    microencapsulation;    tissue engineering;   

DOI  :  10.3390/polym10090997

来源: DOAJ

【 摘 要 】

Stem cell transplantation has been recognized as a promising strategy to induce the regeneration of injured and diseased tissues and sustain therapeutic molecules for prolonged periods in vivo. However, stem cell-based therapy is often ineffective due to low survival, poor engraftment, and a lack of site-specificity. Hydrogels can offer several advantages as cell delivery vehicles, including cell stabilization and the provision of tissue-like environments with specific cellular signals; however, the administration of bulk hydrogels is still not appropriate to obtain safe and effective outcomes. Hence, stem cell encapsulation in uniform micro-sized hydrogels and their transplantation in vivo have recently garnered great attention for minimally invasive administration and the enhancement of therapeutic activities of the transplanted stem cells. Several important methods for stem cell microencapsulation are described in this review. In addition, various natural and synthetic polymers, which have been employed for the microencapsulation of stem cells, are reviewed in this article.

【 授权许可】

Unknown