Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential

eLife

Maria Grazia Vizioli¹  Peter D Adams²  Nirmalya Dasgupta²  Karl N Miller²  Tianhui Liu² 

[1] Cancer Research United Kingdom Beatson Institute, Garscube Estate, Glasgow, United Kingdom;Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States;

关键词: aging;    senescence;    mitochondria;    cytoplasmic chromatin fragments;    epigenetics;   

DOI  :  10.7554/eLife.63728

来源: DOAJ

【 摘 要 】

Senescent cells, damaged cells that permanently exit the cell cycle, play important roles in development, tissue homeostasis, and tumorigenesis. Although many of these roles are beneficial in acute responses to stress and damage, the persistent accumulation of senescent cells is associated with many chronic diseases through their proinflammatory senescence-associated secretory phenotype (SASP). SASP expression is linked to DNA damage; however, the mechanisms that control the SASP are incompletely understood. More recently, it has been shown that senescent cells shed fragments of nuclear chromatin into the cytoplasm, so called cytoplasmic chromatin fragments (CCF). Here, we provide an overview of the current evidence linking DNA damage to the SASP through the formation of CCF. We describe mechanisms of CCF generation and their functional role in senescent cells, with emphasis on therapeutic potential.

【 授权许可】

Unknown