Mitophagy in Yeast: Decades of Research

Cells

Camougrand Nadine¹  Bhatia-Kissova Ingrid² 

[1] CNRS, UMR 5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France;Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 84215 Bratislava, Slovakia;

关键词: yeast;    mitochondria;    quality control;    mitophagy;    Atg32 protein;   

DOI  :  10.3390/cells10123541

来源: DOAJ

【 摘 要 】

Mitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of research on yeasts, which shed light on the molecular mechanisms, regulation, and role of the Atg32 receptor in this process. We analyze the role of ROS in mitophagy and discuss the physiological roles of mitophagy in unicellular organisms, such as yeast; these roles are very different from those in mammals. Additionally, we discuss some of the different tools available for studying mitophagy.

【 授权许可】

Unknown