Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review

Cancers

Maria Teresa Mascellino¹  Alessandra Oliva¹  Rossella Palma²  Cristina Panetta²  Stefano Pontone²  Giulia Scalese³  Giovanni Bruno³  Francesca Aprile³  Carola Severi³ 

[1] Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy;Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy;Department of Translational and Precision Medicine, Gastroenterology Unit, Sapienza University of Rome, 00161 Rome, Italy;

关键词: microbiota;    adenoma;    colorectal cancer;    Proteobacteria;    Fusobacteria;    polyp;   

DOI  :  10.3390/cancers13123061

来源: DOAJ

【 摘 要 】

Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma–carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using “adenoma microbiota” and selecting original articles between January 2010 and May 2020 independently screened. A higher prevalence of Proteobacteria, Fusobacteria, and Bacteroidetes phyla was observed in the fecal luminal and mucosa-associated microbiota of patients with adenoma. However, other studies provided evidence of depletion of Clostridium, Faecalibacterium, Bacteroides and Romboutsia. Results on the relationship between adenoma endoscopic resection and microbiota were inconsistent. In conclusion, none of the analyzed studies developed a predictive model that could differentiate adenoma from non-adenoma patients, and therefore, to prevent cancer progression. The impact of adenoma’s endoscopic resection on microbiota was investigated, but the results were inconclusive. Further research in the field is required.

【 授权许可】

Unknown