N-3 Polyunsaturated Fatty Acids Decrease Long-Term Diabetic Risk of Offspring of Gestational Diabetes Rats by Postponing Shortening of Hepatic Telomeres and Modulating Liver Metabolism

Nutrients

Duo Li¹  Wenwen Cai¹  Jinlong Gao¹  Hailong Xiao²  Xiaofei Guo³  Jiaomei Li³ 

[1] Department of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China;Hangzhou Institute for Food and Drug Control, 198 Yonghua Street, Hangzhou 310022, China;Institute of Nutrition and Health, Qingdao University, 308 Ningxia Road, Qingdao 266071, China;

关键词: gestational diabetes mellitus;    offspring;    long-term effect;    n-3 polyunsaturated fatty acid;    diabetes risk;    liver;    oxidative stress;    inflammation;    telomere length;    metabolomics;   

DOI  :  10.3390/nu11071699

来源: DOAJ

【 摘 要 】

The long-term influence of gestational diabetes mellitus (GDM) on offspring and the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on GDM offspring are poorly understood. We studied the long-term diabetic risk in GDM offspring and evaluated the effect of n-3 PUFA intervention. Healthy offspring rats were fed standard diet (soybean oil) after weaning. GDM offspring were divided into three groups: GDM offspring (soybean oil), n-3 PUFA adequate offspring (fish oil), and n-3 PUFA deficient offspring (safflower oil), fed up to 11 months old. The diabetic risk of GDM offspring gradually increased from no change at weaning to obvious impaired glucose and insulin tolerance at 11 months old. N-3 PUFA decreased oxidative stress and inflammation in the liver of older GDM offspring. There was a differential effect of n-3 PUFA and n-6 PUFA on hepatic telomere length in GDM offspring. Non-targeted metabolomics showed that n-3 PUFA played a modulating role in the liver, in which numerous metabolites and metabolic pathways were altered when GDM offspring grew to old age. Many metabolites were related to diabetes risk, such as α-linolenic acid, palmitic acid, ceramide, oxaloacetic acid, tocotrienol, tetrahydro-11-deoxycortisol, andniacinamide. In summary, GDM offspring exhibited obvious diabetes risk at old age, whereas n-3 PUFA decreased this risk.

【 授权许可】

Unknown