Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19

Antibiotics

Sorin Rugina¹  Mirela Dumitrascu¹  Irina Magdalena Dumitru¹  Romelia Mitan¹  Anca Dumitrescu¹  Licdan Curtali¹  Nicoleta Dorina Vlad¹  Raluca Elena Slujitoru¹  Dalia Sorina Carp¹  Rodica Lesanu¹  Carmen Ilie-Serban¹  Aurelia Hangan¹  Aura Gherghina¹  Corina Mitroi-Maxim¹  Roxana Carmen Cernat¹ 

[1] Clinical Infectious Diseases Hospital, 100 Ferdinand Str, 900709 Constanta, Romania;

关键词: COVID-19;    carbapenemase;    KPC;    carbapenem-resistant Klebsiella pneumoniae;   

DOI  :  10.3390/antibiotics10050561

来源: DOAJ

【 摘 要 】

Infections with carbapenem-resistant Enterobacteriaceae are emerging as an important challenge in healthcare settings. Currently, carbapenem-resistant Klebsiella pneumoniae (CRKP) are the species of CRE most commonly encountered in hospitals. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associated with high rates of morbidity and mortality, particularly among persons with prolonged hospitalization exposed to invasive devices. We report nine patients hospitalized in an intensive care unit (ICU) with severe coronavirus disease 2019 (COVID-19) who developed invasive infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp), KPC and OXA-48, strains that have not been previously identified in our hospital. Despite ceftazidime/avibactam therapy, five patients died. Coinfections can contribute to a poor prognosis for patients with COVID-19, especially for high-risk populations such as elderly patients. Therefore, it is crucial to establish a rigorous program of antibiotic administration in intensive care units.

【 授权许可】

Unknown