Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry

Exploration of Neuroprotective Therapy

Jorge Manzanares¹  Francisco Navarrete¹  Ani Gasparyan²  María S. García-Gutiérrez² 

[1] Red Temática de Investigación Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain;Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain;

关键词: cannabinoid receptor 2;    psychiatry;    emotional response;    anxiety;    depression;    schizophrenia;    bipolar disorder;   

DOI  :  10.37349/ent.2021.00006

来源: DOAJ

【 摘 要 】

Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered as the peripheral cannabinoid receptor due to its detection in the rat spleen and leukocyte subpopulation in humans. Later, CB2R was identified in different brain regions significantly modifying the landscape and pointing out its role in a wide variety of central physiological functions and pathological conditions. Additional research also detected the expression of CB2R in neurons, microglia, and astroglia in different brain regions. Indeed, the findings collected to date support a significant function of CB2R in anxiety, depression, schizophrenia, and additional neuropsychiatric disorders. This review gathers the most relevant literature regarding new advances about the role of CB2R in a variety of neuropsychiatric conditions, with special emphasis on its potential as a new therapeutic target for the treatment of different psychiatric disorders.

【 授权许可】

Unknown