Real-time motion monitoring improves functional MRI data quality in infants

Developmental Cognitive Neuroscience

Amy E. Mirro¹  Deanna J. Greene²  Nico U.F. Dosenbach²  Jeanette K. Kenley³  David F. Montez⁴  Cynthia E. Rogers⁵  Essa Yacoub⁶  Carolina Badke D’Andrea⁷  Sooyeon Sung⁸  Eric A. Earl⁸  Ryland L. Miller⁸  Jonathan M. Koller⁹  Jed T. Elison^1,10  Damien A. Fair^1,11  Christopher D. Smyser^1,11 

[1] Correspondence to: Washington University School of Medicine, 4525 Scott Avenue, Suite 2220, St. Louis, MO 63110, USA.;Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA;Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA;Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA;Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN 55455, USA;Data Science and Sharing Team, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20899, USA;Department of Cognitive Science, University of California San Diego, La Jolla, CA 92093, USA;Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA;Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA;Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA;Institute of Child Development, College of Education and Human Development, University of Minnesota, Minneapolis, MN 55455, USA;

关键词: Functional MRI;    Head motion;    Infant brain;    Neurodevelopment;    Neuroimaging;   

DOI  :  

来源: DOAJ

【 摘 要 】

Imaging the infant brain with MRI has improved our understanding of early neurodevelopment. However, head motion during MRI acquisition is detrimental to both functional and structural MRI scan quality. Though infants are typically scanned while asleep, they commonly exhibit motion during scanning causing data loss. Our group has shown that providing MRI technicians with real-time motion estimates via Framewise Integrated Real-Time MRI Monitoring (FIRMM) software helps obtain high-quality, low motion fMRI data. By estimating head motion in real time and displaying motion metrics to the MR technician during an fMRI scan, FIRMM can improve scanning efficiency. Here, we compared average framewise displacement (FD), a proxy for head motion, and the amount of usable fMRI data (FD ≤ 0.2 mm) in infants scanned with (n = 407) and without FIRMM (n = 295). Using a mixed-effects model, we found that the addition of FIRMM to current state-of-the-art infant scanning protocols significantly increased the amount of usable fMRI data acquired per infant, demonstrating its value for research and clinical infant neuroimaging.

【 授权许可】

Unknown