Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study

Metabolites

MehmetT. Dorak¹  Mansour Alzharani¹  NaserF. Al-Tannak²  DeclanP. Naughton²  Judith Allgrove²  DavidG. Watson³  Simone Benedetti³  AliceE. Thackray³  HannahJ. Moir⁴  Owen Spendiff⁵  Natasha Hill⁵  DavidJ. Stensel⁶ 

[1] Chemistry, Kingston University London, Kingston upon Thames KT1 2EE, UK;;Human Sciences, School of Life Sciences, Pharmacy &;Applied &Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 23924, Safat, Kuwait City 13110, Kuwait;National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK;Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0RE, UK;

关键词: metabolomics;    free fatty acids;    cardiovascular disease;    Type 2 diabetes;    South Asian;    physical activity;    cardiorespiratory fitness;    inflammation;    appetite hormones;    metabolic markers;   

DOI  :  10.3390/metabo9040071

来源: DOAJ

【 摘 要 】

South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass spectrometry), appetite-related hormones and traditional CVD and T2D risk markers in blood samples collected from 16 South Asian and 16 white European men and explored associations with body composition, objectively-measured physical activity and cardiorespiratory fitness. South Asians exhibited higher concentrations of five FFAs (laurate, myristate, palmitate, linolenic, linoleate; p ≤ 0.040), lower acylated ghrelin (ES = 1.00, p = 0.008) and higher leptin (ES = 1.11, p = 0.004) than white Europeans; total peptide YY was similar between groups (p = 0.381). South Asians exhibited elevated fasting insulin, C-reactive protein, interleukin-6, triacylglycerol and ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C) and lower fasting HDL-C (all ES ≥ 0.74, p ≤ 0.053). Controlling for body fat percentage (assessed using air displacement plethysmography) attenuated these differences. Despite similar habitual moderate-to-vigorous physical activity (ES = 0.18, p = 0.675), $\dot{\mathrm{V}}$ O_2max was lower in South Asians (ES = 1.36, p = 0.001). Circulating FFAs in South Asians were positively correlated with body fat percentage (r² = 0.92), body mass (r² = 0.86) and AUC glucose (r² = 0.89) whereas in white Europeans FFAs were negatively correlated with total step counts (r² = 0.96). In conclusion, South Asians exhibited a different FFA profile, lower ghrelin, higher leptin, impaired CVD and T2D risk markers and lower cardiorespiratory fitness than white Europeans.

【 授权许可】

Unknown